![]() The ability to decrease intraocular pressure primarily takes place by lowering aqueous production along with a slight effect from inducing vasoconstriction in the conjunctiva. Nasal decongestive effects occur by the induction of local vasoconstrictive effects in the respiratory microvasculature, which leads to a decrease in edema and airflow resistance. Other lower acuity indications for alpha-1 agonists would include glaucoma (to lower intraocular pressure) and the use of nasal decongestants. Often patients receiving an alpha-1 agonist are concurrently undergoing fluid resuscitation, for example, sepsis or septic shock, cardiopulmonary arrest, and heart failure decompensation. Higher acuity indications for alpha-1 receptor agonists include cases of vasodilatory shock, hypotension, and hypoperfusion. Review interprofessional team strategies for improving care coordination and communication to advance the effective use of alpha-1 adrenergic agonists and improve outcomes.Īlpha-1 adrenergic receptors are present on vascular smooth muscle and myocardial tissue therefore, stimulation causes vasoconstriction and positive inotropic effects, respectively.Outline the appropriate monitoring of selected alpha-1 adrenergic agonists.Describe the adverse effects of selected alpha-1 adrenergic agonists.Identify the mechanism of action of selected alpha-1 adrenergic agonists.This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional team in the management of patients in need of alpha-1 agonistic effects. ![]() This activity reviews the indications, mechanism of action, and contraindications for alpha-1 agonists. Alpha-1 agonists are a class of medications used in the management of many disorders, including vasodilatory shock, hypotension, hypoperfusion, septic shock, cardiopulmonary arrest, heart failure decompensation, as well as other lower acuity conditions.
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